The mission is "to improve the natural and cultural resources at Muscatatuck NWR: also to connect people of all ages to nature and history by providing education, outreach, and wildlife-dependent recreational opportunities".

• In 1997 MWS launched a Foundation that funded the Conservation Learning Center, an addition that doubled the size of the Visitor Center.
• MWS created and manages the Nature Bookstore at the Visitor Center. Proceeds are used for refuge projects.
• MWS is the major financial supporter of the Indiana Junior Duck Stamp Art Contests
• MWS maintains the historic Myers Cabin and Barn (which the refuge cannot afford to do).
• MWS is the primary sponsor of the refuge events and has in the past funded many things the refuge could not do - fishing piers, a bird viewing addition to the Visitors Center, observation decks, Refuge cemetary stone repair, copperbellied water snake research, a children's Nature Discovery Area, courtyard benches, pollinator plantings, and maintenance items